Benzofuranyl aminoalkoxyphenyl compounds

US5039700A · kind A · utility

Assignee

• Sanofi · FR

Inventors

• Jean Gubin · Brussels, BE
• Pierre Chatelain · Brussels, BE
• Marcel Descamps · Kraainem, BE
• Dino Nisato · Pavia, IT
• Henri Inion · Wemmel, BE
• Jean Lucchetti · Chastre, BE
• Jean-Marie Mahaux · Brussels, BE
• Jean-Noel Vallat · Toulouse, FR

Key dates

• Filing date: Mar 19, 1990
• Grant date: Aug 13, 1991
• Expiry date: Mar 19, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group, PA1 R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen, PA1 A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical, PA1 R.sub.3 denotes an alkyl radical or a radical of formula: EQU --Alk--R.sub.5 PA1 in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups, PA1 R.sub.4 denotes hydrogen or an alkyl radical PA1 Cy represents a benzo[b]furyl, as well as the N-oxide derivative thereof and a pharmaceutically acceptable salt thereof.