Photodynamic viral deactivation with sapphyrins

US5041078A · kind A · utility

Assignees

• Baylor Research Foundation, a nonprofit corporation of the State of Texas · US
• The Board of Regents of the University of Texas System · US

Inventors

• J. Lester Matthews · Dallas, US
• Millard M. Judy · Redmond, US
• Joseph T. Newman · Dallas, US
• Frank Sogandares-Bernal · Dallas, US
• Jonathan L. Sessler · Austin, US
• Anthony Harriman · Austin, US
• Bhaskar G. Maiya · Hyderabad, IN

Key dates

• Filing date: Dec 21, 1989
• Grant date: Aug 20, 1991
• Expiry date: Dec 21, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced. One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyr in (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1). The method is particularly suitable for inactivation of viruses in blood and blood products.