Neomorphogenesis of cartilage in vivo from cell culture
US5041138A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 17, 1989 |
| Grant date | Aug 20, 1991 |
| Priority date | — |
| Expiry date | Apr 17, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/919
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate cell volume and density has developed for the cells to survive and proliferate in vivo. One advantage of the matrices is that they can be cast or molded into a desired shape, on an individual basis, so that the final product closely resembles a patient's own ear or nose. Alternatively, flexible matrices can be used which can be manipulated at the time of implantation, as in a joint, followed by remodeling through cell growth and proliferation in vivo. The cultured cells can also be maintained on the matrix in a nutrient media for production of bioactive molecules such as angiogenesis inhibiting factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.