Alpha tocopherol-based vesicles

US5041278A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Andrew S. Janoff · Yardley, US
• Lois E. Bolcsak · Lawrenceville, US
• Alan L. Weiner · Lawrenceville, US
• Paul A. Tremblay · Princeton, US
• Michael V. W. Bergamini · el Masnou, ES

Key dates

• Filing date: Dec 6, 1988
• Grant date: Aug 20, 1991
• Expiry date: Dec 6, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.