Immune system enhancing 3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
US5041426A · kind A · utility
25Cited by
1References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 25, 1988 |
| Grant date | Aug 20, 1991 |
| Priority date | — |
| Expiry date | Aug 25, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the structure: ##STR1## wherein R.sub.4, R.sub.5, R.sub.6 and R.sub.7 individually are H, OH or C.sub.1 -C.sub.18 O-acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR2## or R.sub.5 and R.sub.7 are H or OH, R.sub.6 is H and together R.sub.3 and R.sub.4 are ##STR3## and X is .dbd.O or .dbd.S; Y is --OH, --SH, --Nh.sub.2 or halogen; and Z is H , --Nh.sub.2, --OH or halogen; wherein halogen is Cl or Br; or pharmaceutically acceptable salt thereof are useful as antivirals, antitumors, antimetastatics and as immune system enhancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.