Alkenoic acid derivatives
US5041638A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 9, 1989 |
| Grant date | Aug 20, 1991 |
| Priority date | — |
| Expiry date | May 9, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5407
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond, PA0 W represents --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, PA0 o represents a number 1 to 5, PA0 A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO.sub.2 R.sup.9 or --CH.sub.2 CO.sub.2 R.sup.9 or --CONR.sup.10 R.sup.11 or nitrile PA0 n represents a number 1 to 10, PA0 m represents a number 0 to 7, PA0 T and Z are identical or different and represent oxygen or a direct bond and PA0 R.sup.2, R.sup.3, R.sup.8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro and PA0 R.sup.9 is lower alkyl and R.sup.10 and R.sup.11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ring and pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.