Chroman derivatives for the treatment of depressive states
US5043352A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1989 |
| Grant date | Aug 27, 1991 |
| Priority date | — |
| Expiry date | Nov 22, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treatment of depressive states which comprises administering in mammals in need thereof an effective amount of a compound ##STR1## R.sub.1 represents hydrogen, a halogen atom, a cyano group a nitro group, an acetyl group or a trifluoromethyl group; PA0 R.sub.2 represents a hydroxyl group, in which case R.sub.3 represents a hydrogen atom, or R.sub.2 and R.sub.3 taken together represent an additional bond between the carbon atoms by which they are carried; and PA0 R.sub.4 represents a 2-oxopyrrolidin-1-yl or 2-oxopiperid-1-yl group or a heterocyclic group selected from 1H-pyrid-2-on-1-yl, 1H-pyridazin-6-on-1-yl, 1H-pyrimidin-2-on-1-yl, 1H-pyrimidin-6-on-1-yl, 1H-pyrazin-2-on-1-yl and 1H-thiopyrid-2-on-1-yl groups which are unsubstituted or monosubstituted or disubstituted by a C.sub.1 -C.sub.4 alkyl group, a halogen atom or a hydroxyl, nitro, amino or carboxyl group and the pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.