Process for manufacturing organized collagen structures, particularly of human origin, and organized collagen structures corresponding thereto
US5043426A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 1, 1988 |
| Grant date | Aug 27, 1991 |
| Priority date | — |
| Expiry date | Jul 1, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00365
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention relates to a process for manufacturing organized collagen structures, particularly of human origin and the organized collagen structures corresponding thereto. These organized structures may be either fibres or membranes. According to the process, a specimen of animal or human tissue is ground in a saline solution after washing and aseptization, in order to solubilize the collagen contained in said specimen. There is then added to the extract thus obtained, which is composed of a minimum quantity of collagen fibrils and which is free of non-fibrillary collagen precipitate, a catalyst promoting the reconstitution of collagen fibres. Following a maturation process, the reconstituted organized structures are separated from the aqueous medium by centrifuging, and are then washed, aseptized, conditioned, lyophilized and sterilized. Among the organized structures obtained, the collagen fibers appear in the isolated state, separated from their original cellular tissue, in the form of a web (35), ready for use. They display a periodicity of transverse striations (37) comprised between 68 nm and 72 nm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.