Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5043447A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1988 |
| Grant date | Aug 27, 1991 |
| Priority date | — |
| Expiry date | Oct 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein: R.sup.1 is aryl, lower alkyl, cycloalkyl or hydrogen; PA0 R.sup.2 is aryl, lower alkyl or hydrogen; PA0 R.sup.3 is lower alkyl, hydroxy, or hydrogen; PA0 R.sup.4 is aryl or hydrogen; PA0 R.sup.5 is aryl or hydrogen; PA0 m is two or three; PA0 n is zero, one or two, PA0 provided that when R.sup.3 is hydroxy, n is one or two; and PA0 q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are useful for treating mammals having any of a variety of disease states including: PA0 diseases treated by direct neuronal protection, such as ischemia including focal and global ischemia, spinal injuries, head trauma, and neurological diseases such as Alzheimer's and Huntington's chorea; PA0 diseases treated by inhibition of sodium ion, such as uremic and hyponatremic encephalopathy; and PA0 diseases treated with calcium channel antagonists, including: PA1 diseases treated by inhibiting cerebrovascular vasospasm and by cerebrovascular vasodilation, such as migraine, stroke, vasospasm due to subarachnoid hemorrhage, epilepsy or epileptic psychotic symptoms, and cerebrovascula…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.