Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines

US5045538A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Bruce S. Schneider · Great Neck, US
• Robert A. Greenwald · Melville, US
• Jonathan Maimon · Santa Monica, US
• Kenneth C. Gorray · Floral Park, US
• Lorne M. Golub · Smithtown, US
• Thomas F. McNamara · Port Jefferson, US
• Nangavarum S. Ramamurthy · Smithtown, US

Key dates

• Filing date: Jun 28, 1990
• Grant date: Sep 3, 1991
• Expiry date: Jun 28, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).