Process for controlling intracellular glycosylation of proteins
US5047335A · kind A · utility
204Cited by
7References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 21, 1988 |
| Grant date | Sep 10, 1991 |
| Priority date | — |
| Expiry date | Dec 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/1081
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for controlling the glycosylation of protein in a cell wherein the cell is genetically engineered to produce one or more enzymes which provide internal control of the cell's glycosylation mechanism. A Chinese hamster ovary (CHO) cell line is genetically engineered to produce a sialyltransferase. This supplemental sialyltransferase modifies the CHO glycosylation machinery to produce glycoproteins having carbohydrate structures which more closely resemble naturally occurring human glycoproteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.