1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
US5047420A · kind A · utility
14Cited by
4References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 21, 1989 |
| Grant date | Sep 10, 1991 |
| Priority date | — |
| Expiry date | Aug 21, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediate by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.