Isolation and elucidation of Cephalostatins 5 and 6
US5047532A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1989 |
| Grant date | Sep 10, 1991 |
| Priority date | — |
| Expiry date | Jul 28, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The Indian Ocean (South African) marine worm Cephalodiscus gilchristi (Hemichordata Phylum) has been found to contain a series of unusual disteroidal alkaloids designated the Cephalostatins which demonstrate exceptionally potent lymphocytic leukemia (murine P388) cell line inhibitory activity (to ED.sub.50 10.sup.-9 .mu.g/ml). Two new disteriodal alkaloids bearing aromatic C-rings having ED.sub.50 of 10.sup.-2 and 10.sup.-3 .mu.g/mL were isolated and assigned structures based on rigorous interpretation of two-dimensional 400 MHz.sup.1 H and .sup.13 C-nmr. These substances were denominated Cephalostatin 5 and Cephalostatin 6, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.