Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules
US5049322A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 1987 |
| Grant date | Sep 17, 1991 |
| Priority date | — |
| Expiry date | Dec 31, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The process according to the invention comprises: PA0 (1) the preparation of a liquid phase consisting essentially of a solution of a substance A in a solvent or in a mixture of solvents, and containing the substance B in solution or as a dispersion, PA0 (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B, and supplemented with one or more surfactants, the solvent or mixture of solvents of the first phase being miscible in all proportions with the non-solvent or mixture of non-solvents of the second phase, PA0 (3) the addition of the first phase to the second phase with moderate agitation so as to produce a colloidal suspension of nanocapsules, the wall of which is constituted by the substance A and the core by the substance B, PA0 (4) if desired, the removal of all or part of the solvent or the mixture of solvents and of the non-solvent or the mixture of non-solvents so as to produce a colloidal suspension of nanocapsules of the desired concentration or to produce a powder of nanocapsules following the addition of stabilizing substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.