Osmotically dependent vesicles
US5049392A · kind A · utility
59Cited by
9References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 1989 |
| Grant date | Sep 17, 1991 |
| Priority date | — |
| Expiry date | Jan 18, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Osmotically derived liposomal vesicles loaded with an active agent are disclosed. Liposomes, including an entrapped osmotic agent, are contacted one or more times with a washing solution which is hypotonic to the entrapped osmotic agent and which contains active agent. The entrapped osmotic agent in the liposome and the active agent in the washing solution are each present in concentrations causing the liposomes to swell, rupture under osmotic pressure, spill osmotic agent into the washing solution and re-form to encapsulate active agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.