Insulin derivatives, a process for their preparation, and their use

US5049545A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Hartmut Lobermann · Schallstadt, DE
• Eric-Paul Paques · Marburg, DE
• Norbert Heimburger

Key dates

• Filing date: Mar 15, 1989
• Grant date: Sep 17, 1991
• Expiry date: Mar 15, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Insulin derivatives of the general formulae I and II EQU X--(Y.sub.1 --S--S--Y.sub.2 --Z--"Insulin").sub.m I EQU A--S--Y.sub.3 --Z--"Insulin" II in which PA0 X is a radical of a physiologically tolerated carbon compound, PA0 Y.sub.1, Y.sub.2 and Y.sub.3 are, independently of one another, a chemical bond or an organic chemical bridge, PA0 S is a sulfur atom, PA0 "Insulin" denotes the biologically active peptidic portion of a natural, semisynthetic or synthetic insulin or an insulin which has been prepared by genetic engineering, or one of its biologically active analogs without the inessential amino group, PA0 Z is an amino group which is inessential for the biological activity of insulin, PA0 A is a hydrogen atom or the radical of a mercapto-containing, physiologically tolerated hydrocarbon compound, and PA0 m is an integer from 1 to 20, agents containing these derivatives, a process for the preparation of these derivatives, and their use for the treatment of metabolic disorders, are described.