Rhodomycins with a modified carbohydrate unit

US5049549A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Cenek Kolar · Marburg, DE
• Hans Kraemer · Marburg, DE
• Konrad Dehmel · Marburg, DE

Key dates

• Filing date: Dec 18, 1989
• Grant date: Sep 17, 1991
• Expiry date: Dec 18, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

7-O-Glycosyl-rhodomycins which correspond to the general formula I below ##STR1## in which the radicals have the following meaning: R.sup.1 is a hydrogen atom or a hydroxyl group, PA0 R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl group, PA0 R.sup.3 a hydroxyl group, an O-acyl protective group or the methyloxycarbonyl group, PA0 R.sup.4 is a hydrogen atom, an O-acyl protective group, an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group and PA0 R.sup.5 is an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group, where acyl protective group denotes an acetyl, mono-, di- or trihalogenoacetyl group with fluorine or chlorine as halogen or the p-nitrobenzoyl group, and a process for the preparation thereof and the use thereof as pharmaceuticals, are described.