1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
US5049578A · kind A · utility
12Cited by
7References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1990 |
| Grant date | Sep 17, 1991 |
| Priority date | — |
| Expiry date | Mar 9, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antihypercholesterolemic activity is exhibited by novel compounds of the formula ##STR1## wherein: Z is ##STR2## X is lower alkyl or lower alenyl; R.sup.1 is aryl or alkyl; PA1 R.sup.2 and R.sup.3 are the same or different and are hydrogen, or lower alkyl or aryl, or R.sup.2 and R.sup.3 taken together to form a cycloalkyl group; and PA1 R.sup.4 is hydrogen, lower alkyl, or alkali metal (such as sodium, lithium, or potassium) or a radical such as ammonium. Methods of use and novel intermediates of these compounds are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.