1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-[1,2-a]azepino derivatives and 10-aza, 10-oxa and 10-thia analogues

US5049637A · kind A · utility

Assignees

• MONASH UNIVERSITY · AU
• Australasian Drug Development Limited · AU

Inventors

• Frederick C. Copp · Sydenham, GB
• Alan L. A. Boura · Beaconsfield, AU
• William Roy Jackson · Melbourne, AU
• John D. Cullen · Parkes, AU

Key dates

• Filing date: Dec 7, 1989
• Grant date: Sep 17, 1991
• Expiry date: Dec 7, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## A compound of general formula (I), wherein X=CH.sub.2, O, S or NR.sup.4, and Y=formula (II): where R.sup.1 =H, lower alkyl or an aryloxyalkyl group, wherein the aryl group is optionally substituted by alkyl, alkoxy, hydrogen, alkyl substituted by hydrogen, and n is an integer between 0 and 5, and Z=O, S or NR.sup.2 ; wherein R.sup.2 =H, lower alkyl, hydroxy, amino cyano or acyl, R.sup.3 =H, or lower alkyl, and R.sup.4 =H, lower alkyl, or lower acyl, and pharmaceutically acceptable salts thereof.