Tripeptide compounds having hypotensive activity

US5051404A · kind A · utility

Assignees

• Eniricerche S.p.A. · IT
• Polifarma S.p.A. · IT

Inventors

• Alessandro Sisto · Roma, IT
• Antonio S. Verdini · Monterotondo, IT
• Antonino Virdia · Roma, IT
• Giovanna De Luca · Roma, IT
• Giovanni Di Stazio · Roma, IT
• Vincenzo Politi · Roma, IT

Key dates

• Filing date: Sep 20, 1988
• Grant date: Sep 24, 1991
• Expiry date: Sep 20, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/80
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Tripeptides having hypotensive activity, defined by the following general formula: EQU A--B--C--OZ (I) wherein: PA1 A represents a residue of L-pyroglutamic acid, L-proline of L-proline bearing a substituent on its amino group ##STR1## wherein R.sub.1 is an acyl with a number of carbon atoms in straight chain not higher than 9, a benzyloxycarbonyl group or an alkyloxycarbonyl group; PA1 B is an .alpha.-aminoacide residue derived from one of the natural aminoacids; PA1 C is a residue of L-tryptophan (Trp), of L-phenylalanine (Phe) or of L-tyrosine (Tyr); PA1 Z is a hydrogen atom or an alkyl group with a number of carbon atoms in straight chain not higher than 9.