In vitro test for dermal toxic properties
US5053340A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1989 |
| Grant date | Oct 1, 1991 |
| Priority date | — |
| Expiry date | Feb 24, 2009 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5014
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A membrane support, reagent and method determines, in vitro, skin irritation properties of individual compounds and/or mixtures is disclosed. The material to be tested is applied directly to the membrane support. The material may penetrate the membrane and diffuse into the reagent and cause a response, for example, the production of a precipitate. The test material may also alter or destroy the membrane and/or disrupt covalently linked dye molecules attached to the membrane and diffuse into the reagent to produce an additional or alternate response--for example, color. The sum of these two responses is proportional to the deleterious response elicited by the material on the human skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.