Compositions for photodynamic therapy
US5053423A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 22, 1990 |
| Grant date | Oct 1, 1991 |
| Priority date | — |
| Expiry date | Mar 22, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/61
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Porphyrin-type photosensitizers useful in photodynamic therapy can be formulated as water soluble drugs by conjugation of the photosensitizer to a hydrophilic polymer. Conjugation of the photosensitizer in varying ratios to the polymer, such as polyvinyl alcohol, provides compositions which are readily soluble and biodistribute in a fashion equal to or advantageous over that obtained when the photosensitizer is administered alone. In addition, these conjugates which further a contain target specific component provide a mechanism for homing to the desired target tissue, as well as offering a convenient approach to including both target specific component and photosensitizing drug in the same complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.