Simplified thioester and isostere analogs of oleoyl coenzyme a as hypocholesterolemic agents
US5053426A · kind A · utility
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7Claims
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Key dates
| Filing date | Mar 29, 1990 |
| Grant date | Oct 1, 1991 |
| Priority date | — |
| Expiry date | Mar 29, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is selected from the group consisting of --S--, --O--, --NH-- and (--CH.sub.2 --).sub.n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), ##STR3## wherein R=Hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 acyl, and ##STR4##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.