Lysis of fibrin blood clots with urokinase and pro-urokinase

US5055295A · kind A · utility

Assignee

• Vascular Laboratory, Inc. · US

Inventors

• Dieter Welzel · Nuremberg, DE
• Helmut Wolf · Holzkirchen, DE

Key dates

• Filing date: May 2, 1989
• Grant date: Oct 8, 1991
• Expiry date: May 2, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The thrombolytic effect of the plasminogen activator pro-urokinase is improved synergistically by the co-administration of urokinase. The two components may be administered sequentially or simultaneously, and if simultaneously, either separately or as a mixture. Preferably an initial bolus injection of urokinase is followed by an infusion of pro-urokinase.