Sustained-release formulations
US5055306A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1988 |
| Grant date | Oct 8, 1991 |
| Priority date | — |
| Expiry date | Oct 20, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A granular sustained-release formulation of a pharmacologically active substance presented in the form of a tablet, said tablet comprising sufficient granules to provide a predetermined dose or number of doses of the pharmacologically active substance and effervescent or water-dispersible ingredients, each of said granules having a diameter of preferably between 0.5 and 2.5 mm and comprising: PA0 a) a core comprising one or more pharmacologically active substances and preferably one or more excipients; and PA0 b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25% of the weight of the core. A method for preparing this effervescent of water-dispersible tablet formulation is also provided. Such formulations enable large dosages in sustained-release form to be more easily administered to patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.