Patent · US Expired

Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors

US5055451A · kind A · utility

65Cited by

5References

50Claims

0Family size

Assignee

Syntex LLC · PA

Inventors

Alexander Krantz · San Francisco, US
Heinz W. Pauls · Oakville, CA
Roger Smith · Madison, US
Robin Spencer · Mississauga, CA

Key dates

Filing date	Dec 7, 1987
Grant date	Oct 8, 1991
Priority date	—
Expiry date	Dec 7, 2007

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: PA0 n is 0 or 1; PA0 m is 0, 1 or 2; PA0 X is H or an N-protecting group; PA0 each Y is independently an optionally protected .alpha.-amino acid residue; PA0 R is an optionally protected .alpha.-amino acid side chain that is H or CH.sub.3 or that is bonded to the .alpha.-carbon atom to which it is attached by a methylene, methine or phenyl radical; and PA0 R' is optionally substituted aryl.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.