Purine derivatives having antiviral activity
US5055458A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1989 |
| Grant date | Oct 8, 1991 |
| Priority date | — |
| Expiry date | Jul 28, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6512
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is hydroxy, amino, chloro or OR.sub.7 wherein PA0 R.sub.7 is C.sub.1-6 alkyl, phenyl or phenyl C.sub.1-2 alkyl either of which phenyl moieties may be substituted by one or two substituents selected from halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; PA0 R.sub.2 amino or, when R.sub.1 is hydroxy or amino, R.sub.2 may also be hydrogen; PA0 X is --CH.sub.2 CH.sub.2 -- or a moiety of structure (a), (b) or (c): ##STR2## wherein n is 1 or 2; PA0 m is 0, 1 or 2; and PA0 R.sub.3 is hydrogen or acyl; PA0 R.sub.4 is a group of formula: ##STR3## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, C.sub.1-6 alkyl and optionally substituted phenyl; having antiviral activity, processes for their preparation and their use as pharmaceuticals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.