P-hydroxy phenone derivatives and drugs containing these

US5055475A · kind A · utility

Assignee

• BASF SE

Inventors

• Wilfried Lubisch · Mannheim, DE
• Gerda von Philipsborn · Weinheim, DE

Key dates

• Filing date: Jul 6, 1990
• Grant date: Oct 8, 1991
• Expiry date: Jul 6, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

P-hydroxy phenone derivatives of the formula 1 ##STR1## where X is ##STR2## where R.sup.1 =F, Cl, Br or trifluoromethyl or a heteroaryl of the structure ##STR3## with R.sup.2 =C.sub.1 -C.sub.4 - alkyl, PA0 Y is a bridging member of the formula --CH.dbd.CH--, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 --, PA0 n is one of the numbers 2, 3 or 4 and PA0 Z is an amino group of the formula --NR.sup.2 R.sup.3 or N--pyrrolidyl or N-piperidyl, where R.sup.2 and R.sup.3 are, independently of one another, C.sub.1 -C.sub.4 -alkyl, as well as the physiologically tolerated salts thereof, are used for preparing antiarrhythmic drugs.