Process for preparing 1,5-benzothiazepine derivatives
US5055575A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1990 |
| Grant date | Oct 8, 1991 |
| Priority date | — |
| Expiry date | Apr 30, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed a process for preparing 1,5-benzothiazepine derivatives represented by the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 is a lower alkyl group or halogen atom, and the other is hydrogen atom, R.sup.3 is a lower alkyl group or a lower alkoxy group, which comprises subjecting a propionic acid compound represented by the formula (II): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meanings as defined above, and R.sup.4 represents hydrogen atom or an ester residue, to intramolecular ring closing reaction in the presence of a sulfonic acid compound represented by the formula (III): EQU R.sup.5 SO.sub.3 H (III) wherein R.sup.5 represents a lower alkyl group or a substituted or unsubstituted phenyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.