Process for preparing prostaglandin analogs using organozirconium compounds
US5055604A · kind A · utility
3Cited by
12References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1990 |
| Grant date | Oct 8, 1991 |
| Priority date | — |
| Expiry date | Apr 17, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a prostaglandin derivative by reacting an alkyne with zirconocene chloride hydride to produce a zirconium intermediate which is reacted with an alkyllithium and a first copper reagent selected from R.sup.2 Cu(CN)Li or the mixture CuCN and R.sup.2 Li to produce a higher order cuprate complex intermediate and reacting the higher order cuprate complex intermediate with a cyclopentenone to produce the prostaglandin derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.