Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US5057301A · kind A · utility
34Cited by
27References
12Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 6, 1988 |
| Grant date | Oct 15, 1991 |
| Priority date | — |
| Expiry date | Apr 6, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6889
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified cellular substrates are used as linking groups that are recognized as cellular substrates by intracellular metabolic enzymes. The linking groups function to attach a ligand, such as a drug or radionuclide, to a targeting protein, such as an antibody or antibody fragment. The false substrate structure of the linking groups causes increased cellular retention of the linking group/ligand conjugate because the enzymes used for catabolism of the substrate are inhibited by the false substrate structure of the linking group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.