Diagnostic and therapeutic antibody conjugates
US5057313A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 23, 1988 |
| Grant date | Oct 15, 1991 |
| Priority date | — |
| Expiry date | Aug 23, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as an aminodextran or a polypeptide of at least 50 amino acids in length, and this intermediate is in turn site-specifically conjugated to a targeting antibody such as an antitumor antibody. The resultant conjugate substantially retains the immunoreactivity of the antibody, and targets the diagnostic or therapeutic principle to a target tissue or organ where the diagnostic or therapeutic effect is realized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.