Pharmaceutical compositions of cimetidine

US5057319A · kind A · utility

Assignee

• Smith Kline Dauelsberg GmbH · DE

Inventors

• Eberhard F. Gottwald · Bovenden, DE
• Hermann Osterwald · Glückstadt, DE
• Horst M. Machoczek · Rosdorf, DE
• David Mayron · Blue Bell, US

Key dates

• Filing date: Dec 20, 1988
• Grant date: Oct 15, 1991
• Expiry date: Dec 20, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a pharmaceutical granule composition comprising cimetidine and, as a granulating agent and taste-masking agent, an ester of a polyhydroxy compound, and where desired a palatable pharmaceutically acceptable emulsifier. Particular esters are glycerol esters. The granules of the present invention can be used in the preparation of chewable tablets which have good palatability and bioavailability.