Method for resolution of stereoisomers
US5057427A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1988 |
| Grant date | Oct 15, 1991 |
| Priority date | — |
| Expiry date | Apr 7, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a novel method of effecting aqueous enzymatic and homogeneous resolutions of racemic esters which exhibit enhanced aqueous solubility. The preferred embodiment of this invention relates to the resolutions which are effected by placing the enzyme and racemic esters in an aqueous phase wherein one of the ester enantiomers is preferentially and stereospecifically de-esterified to effect the resolution of the initial racemic mixture. In another embodiment of this invention, the resolutions are effected by placing the enzyme and racemic esters in an aqueous phase, and contacting this aqueous phase with an organic phase. The preferential and stereospecific de-esterification of one of the ester enantiomers is effected, and the chiral acid product of the de-esterification reaction is extracted into the organic phase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.