2,3-substituted 1,8-naphthyridines, their preparation and their use as antidotes

US5059240A · kind A · utility

Assignee

• BASF SE

Inventors

• Helmut Hagen · Bischofswerda, DE
• Juergen Pfister · Speyer, DE
• Hans Ziegler · Mutterstadt, DE
• Bruno Wuerzer · Otterstadt, DE
• Karl-Otto Westphalen · Speyer, DE

Key dates

• Filing date: Mar 1, 1990
• Grant date: Oct 22, 1991
• Expiry date: Mar 1, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2,3-substituted 1,8-naphthyridines of the general formula I ##STR1## where: R is hydrogen or C.sub.1 -C.sub.4 -alkyl (n=1 or 2) PA0 R.sup.1 is amino or substituted amino, PA1 XR.sup.5, where X is oxygen or sulfur and R.sup.5 is hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.1 -C.sub.4 -alkoxycarbonyl-((C.sub.1 -C.sub.4)-alkyl, C.sub.5 -C.sub.8 -cycloakyl, substituted or unsubstituted phenyl, substituted or unsubstituted phenyl-(C.sub.1 -C.sub.3)-alkyl, PA1 halogen, PA1 isothiorhonium halide, PA1 C.sub.1 -C.sub.12 -alkyl, PA1 C.sub.1 -C.sub.4 -alkoxycarbonyl-C.sub.1 -C.sub.4 -alkyl, PA1 substituted or unsubstituted phenyl or phenyl-(C.sub.1 -C.sub.3)-alkyl, PA0 R.sup.2 is C.sub.1 -C.sub.4 -alkyl, cyano, carboxyl or a group ##STR2## where X is oxygen or sulfur, PA1 B is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or alkylthio, amino, mono- or dialkylamino, where each alkyl radical is of 1 to 4 carbon atoms, morpholino, piperidyl, chlorine, bromine or substituted or unsubstituted phenyl, PA1 D is C.sub.1 -C.sub.4 alkyl or NH.sub.2 and PA1 R.sup.6 is hydrogen, C.sub.1 -C.sub.8 -alkyl or alkylcarbonyl, PA1 or R.sup.1 and R.sup.2 together are --NH--N.dbd.C(CH.sub.2)--, PA0 and their env…