Preparation of targeted liposome systems of a defined size distribution
US5059421A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1989 |
| Grant date | Oct 22, 1991 |
| Priority date | — |
| Expiry date | Jun 23, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6911
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm. The liposomes of the invention may have a transmembrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineplastic agents, and may be used in diagnostic assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.