Antimycotically active cyclopropyl-substituted azolylmethylcarbinols

US5059615A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Burkhard Fugmann · Wülfrath, DE
• Manfred Plempel · Haan, DE
• Klaus Stroech · Solingen, DE
• Karl H. Buchel · Burscheid, DE

Key dates

• Filing date: Nov 1, 1989
• Grant date: Oct 22, 1991
• Expiry date: Nov 1, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antimycotically active 1-cyano- and 1-carboxamidocyclopropylazolylmethylcarbinols have now been found of the formula ##STR1## in which R.sup.1 represents hydrogen or represents alkyl or represents alkylcarbonyl, PA1 R.sup.2 represents cyano or represents a group of the formula ##STR2## R.sup.3 represents phenyl which is optionally substituted by halogen, straight-chain or branched alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio, or by phenyl or phenoxy which, in turn, may be substituted by halogen or alkyl having up to 6 carbon atoms, PA1 X represents a nitrogen atom or the CH group, PA1 Y represents a bond or represents a group of the formula ##STR3## in which R.sup.4 and R.sup.5 are identical or different and denote hydrogen or alkyl and their pharmaceutically tolerated acid addition salts.