Analgesic oxazolopyridine compounds

US5061713A · kind A · utility

Assignee

• Science et Organization · FR

Inventors

• Gerald Guillaumet · Orléans, FR
• Christine Flouzat · Orléans, FR
• Jacqueline Bonnet · Paris, FR

Key dates

• Filing date: Aug 7, 1990
• Grant date: Oct 29, 1991
• Expiry date: Aug 7, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compound of general formula (I): ##STR1## in which: X, Y, Z and T each represent, independently of one another, a nitrogen atom, a --CH.dbd. group or a group CW, in which W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as a trifluoromethyl group, on condition that only one of them represents a nitrogen atom, PA0 Ra, Rb, Rc, Rd and Re represent, independently of one another, a hydrogen atom, a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as a trifluoromethyl group, PA0 B represents a hydrogen atom and D a hydroxyl group, or B and D simultaneously represent an oxygen atom, PA0 n represents 1 or 2, and PA0 R.sub.1 represents a hydrogen atom, a linear or branched lower alkyl, linear or branched lower alkenyl, aryl or lower arylalkyl group or a cycloalkyl group having 3 to 7 carbon atoms, it being possible for each of the lower alkyl, lower alkenyl, aryl, lower arylalkyl and cycloalkyl groups to be substituted with one or more halogen atoms or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as a trifluoromethyl gr…