Corticotropin-releasing factor antagonism compounds
US5063245A · kind A · utility
75Cited by
0References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1990 |
| Grant date | Nov 5, 1991 |
| Priority date | — |
| Expiry date | Mar 28, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexia nervosa, cardiovascular abnormalities and stress-induced immune suppression. The invention also relates to compounds (4-substituted thio-5-oxo-3-pyrazolines) and to pharmaceutical compositions suitable for use in such a method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.