HMG-COA reductase-inhibiting imino-substituted pyridines

US5064841A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rolf Angerbauer · Wuppertal, DE
• Peter Fey · Wuppertal, DE
• Walter Hubsch · Wuppertal, DE
• Thomas Philipps · Cologne, DE
• Hilmar Bischoff · Wuppertal, DE
• Dieter Petzinna · Mülheim an der Ruhr, DE
• Delf Schmidt · Wuppertal, DE

Key dates

• Filing date: Jul 26, 1990
• Grant date: Nov 12, 1991
• Expiry date: Jul 26, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

HMG-CoA reductase-inhibiting imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl, PA0 R.sup.2 is optionally substituted aryl or alkyl, OH, alkoxy, aralkoxy, or optionally substituted aryloxy, PA0 R.sup.3 is cycloalkyl, or optionally substituted aaryl or alkyl, PA0 R.sup.4 is alkyl or cycloalkyl, PA0 X is --CH.sub.2 --CH.sub.2 -- or .sub.[CH.dbd.CH--, PA0 R is ##STR2## R.sup.6 is H or alkyl, and R.sup.7 is H, alkyl, phenylalkyl, aryl or a cation, and their salts.