N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5066655A · kind A · utility
13Cited by
15References
4Claims
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Key dates
| Filing date | Oct 6, 1989 |
| Grant date | Nov 19, 1991 |
| Priority date | — |
| Expiry date | Oct 6, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of 15 N.sup.6 -substituted 9-methyladenines have been assessed as antagonists of A.sub.2 -adenoisine receptor-mediated stimulation of adenylate cyclase in membranes of hman platelets and rat PC12 cells and of A.sub.1 -adenosine receptor-mediated inhibition of adenylate cyclases in membranes of rat fat cells and as inhibitors of binding of N.sup.6 -R-[.sup.3 H]-phenylisopropyladenosine to A.sub.1 adenosine receptors in rat brain membranes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.