Process for preparing cepham intermediates
US5066797A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 10, 1989 |
| Grant date | Nov 19, 1991 |
| Priority date | — |
| Expiry date | Jul 10, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is described a process for producing exomethylene cepham intermediates useful in cephalosporin chemistry. The process comprises the preparation of a compound of the formula ##STR1## in which R.sup.1 is an amino group, a protected amino group, an acylamino group or a diacylamino group, PA0 R.sup.2 is hydrogen, C.sub.1-4 alkoxy or C.sub.1-4 alkylthio, PA0 R.sup.3 is hydrogen, a salt ion or an ester-forming group, and PA0 R.sup.4 is hydrogen or C.sub.1-3 alkyl, by reacting a compound of the formula ##STR2## in which Y is a bridging group of the formula ##STR3## Z is chloro, bromo or iodo, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the above defined values, with a reagent providing cobalt I, under reducing conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.