Process for the preparation of castanospermine
US5066807A · kind A · utility
5Cited by
0References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 12, 1990 |
| Grant date | Nov 19, 1991 |
| Priority date | — |
| Expiry date | Mar 12, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Castanospermine is prepared by starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene-.alpha.-D-glucuronolactone. Two additional carbons are added to the starting material using ethyl acetate and a strong base and the resulting cyclic hemiketal is subjected to a series of reductions, with intervening removal of protecting groups, to give the castanospermine. A substituted hydroxypyrrolidinone and a substituted hydroxypyrrolidine serve as intermediates in the process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.