1,4-dihydropyridines and their ability to inhibit blood platelet aggregation, inhibit thromboxane synthetase and phospholipase

US5068337A · kind A · utility

Assignee

• John Wyeth & Brother Limited · GB

Inventors

• John L. Archibald
• Terence J. Ward
• Albert Opalko · Maidenhead, GB

Key dates

• Filing date: Nov 13, 1986
• Grant date: Nov 26, 1991
• Expiry date: Nov 13, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of formula ##STR1## or salts thereof; wherein Ar is an optionally substituted aryl radical; PA1 R represents hydrogen or an optionally substituted alkyl or aralkyl group; PA1 R.sup.1 and R.sup.2 are the same or different and are selected from hydrogen and saturated or unsaturated, cyclic or acyclic aliphatic hydrocarbon residues optionally substituted by one or more groups selected from halogen, OH, carboxy, CN, alkoxy, alkylthio, aryloxy, alkoxycarbonyl, amino, substituted amino, and optionally substituted aryl; PA1 A represents a group of formula --XR.sup.3 wherein PA2 X is (i) a group of formula --(CHR.sup.6).sub.p --Y--(CHR.sup.7).sub.q --or (ii) a group of formula --(CHR.sup.6).sub.r --O--(CHR.sup.7).sub.q in which formulae: Y represents --S--, NR.sup.8 or a direct bond, p and q each represent 0, 1 or 2 providing that p and q do not both represent 0, 1 or 2 and the other is zero; R.sup.6, R.sup.7 and R.sup.8 independently represent hydrogen or lower alkyl, and R.sup.3 is an optionally substituted nitrogen ring heteroaryl radical optionally containing other ring heteroatoms selected from oxygen, nitrogen or sulphur; B represents hydrogen, carbox…