Solubilized pro-drugs
US5070082A · kind A · utility
27Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 18, 1991 |
| Grant date | Dec 3, 1991 |
| Priority date | — |
| Expiry date | Mar 18, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65583
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.