Substituted N-glycosylamides, process for their preparation, and their use as medicaments

US5070190A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Oswald Lockhoff · Cologne, DE
• John Goossens · Cologne, DE
• Helmut Brunner · Wuppertal, DE
• Michael Sperzel · Wuppertal, DE
• Klaus G. Stunkel · Wuppertal, DE

Key dates

• Filing date: Apr 12, 1989
• Grant date: Dec 3, 1991
• Expiry date: Apr 12, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms, PA0 R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms, PA0 A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, and PA0 n represents 0 to 10, and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.