Melphalan derivatives

US5075108A · kind A · utility

Assignee

• Consolidated Pharmaceuticals, Limited · AU

Inventors

• Ian F. C. McKenzie · Brunswick, AU
• Geoffrey Allan Pietersz · Melbourne, AU
• Mark Smyth · Melbourne, AU

Key dates

• Filing date: Dec 21, 1987
• Grant date: Dec 24, 1991
• Expiry date: Dec 21, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula I ##STR1## wherein R.sub.1 is of formula II ##STR2## wherein R.sub.4 and R.sub.5, which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl; PA1 R.sub.2 is of formula III ##STR3## wherein R.sub.6 and R.sub.7, which may be the same or different, are H, alkyl, aryl, carboxy, hydroxy or amino and n is 0-10; and PA1 R.sub.3 is hydroxy or a group capable of being cleared and replaced by a radical having an antigen binding site or R.sub.3 is a radical having an antigen binding site.