Process for the preparation of a pharmaceutical which contains IgG, IgA and IgM and can be administered intravenously

US5075425A · kind A · utility

Assignee

• Biotest Pharma GmbH · DE

Inventors

• Ronald Kotitschke · Dreieich, DE
• Wolfgang Stephan · Heidelberg, DE
• Wolfgang Moller · Lübeck, DE
• Detlef Piechaczek · Munster, DE
• Dieter Rudnick · Dreieich, DE

Key dates

• Filing date: Aug 1, 1990
• Grant date: Dec 24, 1991
• Expiry date: Aug 1, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Process for the preparation of an immunoglobulin solution suitable for intravenous administration from a human blood protein fraction containing immunoglobulins IgG, IgA and IgM in partially concentrated from, with the process steps: addition of acetate buffer to the protein fraction, where appropriate removal of insoluble constituents by filtration, treatment with calcium phosphate and octanoic acid, centrifugation, removal of the supernatant and treatment thereof with an adsorbent, removal of the adsorbent and sterilization by filtration.