Pyrrolimidazolones useful as renin inhibitors
US5075451A · kind A · utility
32Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 16, 1990 |
| Grant date | Dec 24, 1991 |
| Priority date | — |
| Expiry date | Nov 16, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alkyl, phenyl, benzyl or phenethyl; Y is --CH.sub.2 --, --NH-- or --O--; and Z is --H.sub.2 or .dbd.O; B is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl or phenylalkyl; or a pharmaceutically acceptable salt thereof are renin inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.