Method for membrane reactor resolution of stereoisomers
US5077217A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1988 |
| Grant date | Dec 31, 1991 |
| Priority date | — |
| Expiry date | Apr 7, 2008 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00177
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to novel methods for facilitating the enzymatic resolution of racemic mixtures of esters, which are derivatized with groups which enhance the esters' aqueous solubility, in an extractive member reactor where the enzyme is placed alternatively either (1) in the aqueous phase, (2) in association with the membrane, or (3) in the aqueous phase and in association with the membrane, wherein the aqueous ester phase is contacted with one side of the membrane, and where an organic extractive phase is contacted with the other side of the membrane, wherein the extractive phase serves to remove the resolving reaction product. Of particular significance regarding this invention is its use of water soluble esters that are derivatized with groups which enhance their aqueous solubility and their reactivity with enzymatic resolving methods which are mediated in an aqueous environment. Novel methods were utilized to prepare these esters, for use in this invention's methods for enzymatically resolving the racemic mixtures of the esters, to produce the separate chiral isomers of the racemic mixture. The importance of the resolution of the separate chiral isomers of the racemic m…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.